Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan

Abstract

Using the GISAID EpiCoV database, we identified 256 COVID-19 patients in Japan during March 31–December 31, 2023, who had mutations in the SARS-CoV-2 nonstructural protein 5 conferring ensitrelvir resistance. Ongoing genomic surveillance is required to monitor emergence of SARS-CoV-2 mutations that are resistant to anticoronaviral drugs.

Keywords

• COVID-19
• ensitrelvir
• SARS-CoV-2
• severe acute respiratory syndrome coronavirus 2
• SARS
• coronavirus disease