Nature Communications (Nov 2017)
Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells
- Pamela P. Lee,
- Damián Lobato-Márquez,
- Nayani Pramanik,
- Andrea Sirianni,
- Vanessa Daza-Cajigal,
- Elizabeth Rivers,
- Alessia Cavazza,
- Gerben Bouma,
- Dale Moulding,
- Kjell Hultenby,
- Lisa S. Westerberg,
- Michael Hollinshead,
- Yu-Lung Lau,
- Siobhan O. Burns,
- Serge Mostowy,
- Mona Bajaj-Elliott,
- Adrian J. Thrasher
Affiliations
- Pamela P. Lee
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Damián Lobato-Márquez
- Section of Microbiology, MRC Centre of Molecular Bacteriology and Infection, Imperial College London
- Nayani Pramanik
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Andrea Sirianni
- Section of Microbiology, MRC Centre of Molecular Bacteriology and Infection, Imperial College London
- Vanessa Daza-Cajigal
- University College London Institute of Immunity and Transplantation
- Elizabeth Rivers
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Alessia Cavazza
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Gerben Bouma
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Dale Moulding
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Kjell Hultenby
- Karolinska Institutet, Department of Laboratory Medicine
- Lisa S. Westerberg
- Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology
- Michael Hollinshead
- Department of Pathology, University of Cambridge
- Yu-Lung Lau
- Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong
- Siobhan O. Burns
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Serge Mostowy
- Section of Microbiology, MRC Centre of Molecular Bacteriology and Infection, Imperial College London
- Mona Bajaj-Elliott
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- Adrian J. Thrasher
- Infection, Immunity and Inflammation Program, Great Ormond Street Institute of Child Health, University College London
- DOI
- https://doi.org/10.1038/s41467-017-01676-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.
