JACC: Basic to Translational Science (Oct 2019)
Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway
- Mathilde Prud’homme, PhD,
- Maxime Coutrot, MD, MSc,
- Thibault Michel, MD, MSc,
- Louis Boutin, MD, MSc,
- Magali Genest, PhD,
- Françoise Poirier, PhD,
- Jean-Marie Launay, PharmD, PhD,
- Bocar Kane,
- Satoshi Kinugasa, MD, PhD,
- Niki Prakoura, PhD,
- Sophie Vandermeersch,
- Alain Cohen-Solal, MD, PhD,
- Claude Delcayre, PhD,
- Jane-Lise Samuel, MD, PhD,
- Ravindra Mehta, MD,
- Etienne Gayat, MD, PhD,
- Alexandre Mebazaa, MD, PhD,
- Christos E. Chadjichristos, PhD,
- Matthieu Legrand, MD, PhD
Affiliations
- Mathilde Prud’homme, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France
- Maxime Coutrot, MD, MSc
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France
- Thibault Michel, MD, MSc
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France
- Louis Boutin, MD, MSc
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France
- Magali Genest, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; INSERM UMR-S 1155, Tenon Hospital, Paris, France
- Françoise Poirier, PhD
- Institut Jacques Monod, Team: Morphogenesis, Homeostasis and Pathologies, Paris, France
- Jean-Marie Launay, PharmD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France
- Bocar Kane
- UMS-28 Phénotypage du petit animal, Université Pierre et Marie Curie, Paris, France
- Satoshi Kinugasa, MD, PhD
- INSERM UMR-S 1155, Tenon Hospital, Paris, France
- Niki Prakoura, PhD
- INSERM UMR-S 1155, Tenon Hospital, Paris, France
- Sophie Vandermeersch
- INSERM UMR-S 1155, Tenon Hospital, Paris, France
- Alain Cohen-Solal, MD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; Cardiology Department, Lariboisière Hospital, Paris, France
- Claude Delcayre, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France
- Jane-Lise Samuel, MD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France
- Ravindra Mehta, MD
- Department of Medicine, University of California-San Diego, San Diego, California
- Etienne Gayat, MD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France
- Alexandre Mebazaa, MD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France
- Christos E. Chadjichristos, PhD
- INSERM UMR-S 1155, Tenon Hospital, Paris, France
- Matthieu Legrand, MD, PhD
- INSERM UMR-S 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Lariboisière Hospital, and INI-CRCT-F-CRIN, Paris, France; AP-HP, St-Louis-Lariboisière Hospital, Department of Anesthesiology and Critical Care and Burn Unit, University Paris Diderot, Paris, France; Department of Anesthesiology and peri-operative Care, University of California San Francisco, United States; Address for correspondence: Dr. Matthieu M. Legrand, Department of Anesthesiology and Peri-Operative Care, University of California San Francisco, 500 Parnassus Avenue, E410, San Francisco, California 94117.
- Journal volume & issue
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Vol. 4,
no. 6
pp. 717 – 732
Abstract
Summary: Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway. Key Words: fibrosis, heart failure, inflammation, macrophages, renal failure
