Indicators of oxidative stress in patients with chronic obstructive pulmonary disease of varying severity in the acute stage

Abstract

During the course of chronic obstructive pulmonary disease (COPD) and it's progression occurs oxidative stress (OS) is characterized as a shift of pro-/anti-oxidants in the direction of the first link. For a comprehensive evaluation of the operating system used was an integral indicator of prooksidant-/antioxidant systems - a combo of blood. A significant increase in this index during exacerbation of COPD show a sharp imbalance in the pro-/anti-oxidants. Installed opposite changes of indicators of activity of enzymes of the antioxidant protection (AOP) of red blood cells, with a sharp oppression of non-enzymatic link of AOP, which is an additional adverse factor in the functioning of the antioxidant system. Identified significant oxidative changes in patients with COPD give ground to the additional purpose of drug therapy, with strong directional antihypoxic and antioxidant effects.

Keywords

• антиоксиданты
• окислительный стресс
• обструктивная болезнь легких
• antioxidants
• oxidative stress
• obstructive pulmonary disease