Nature Communications (Jul 2017)
Triggerable tough hydrogels for gastric resident dosage forms
- Jinyao Liu,
- Yan Pang,
- Shiyi Zhang,
- Cody Cleveland,
- Xiaolei Yin,
- Lucas Booth,
- Jiaqi Lin,
- Young-Ah Lucy Lee,
- Hormoz Mazdiyasni,
- Sarah Saxton,
- Ameya R. Kirtane,
- Thomas von Erlach,
- Jaimie Rogner,
- Robert Langer,
- Giovanni Traverso
Affiliations
- Jinyao Liu
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Yan Pang
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Shiyi Zhang
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Cody Cleveland
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Xiaolei Yin
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Lucas Booth
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Jiaqi Lin
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Young-Ah Lucy Lee
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Hormoz Mazdiyasni
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Sarah Saxton
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Ameya R. Kirtane
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Thomas von Erlach
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Jaimie Rogner
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Robert Langer
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Giovanni Traverso
- Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-017-00144-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.
