A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

Mark A. Lobas; Rongkun Tao; Jun Nagai; Mira T. Kronschläger; Philip M. Borden; Jonathan S. Marvin; Loren L. Looger; Baljit S. Khakh

doi:10.1038/s41467-019-08441-5

Nature Communications (Feb 2019)

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

Mark A. Lobas,
Rongkun Tao,
Jun Nagai,
Mira T. Kronschläger,
Philip M. Borden,
Jonathan S. Marvin,
Loren L. Looger,
Baljit S. Khakh

Affiliations

Mark A. Lobas: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Rongkun Tao: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Jun Nagai: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Mira T. Kronschläger: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles
Philip M. Borden: Janelia Research Campus
Jonathan S. Marvin: Janelia Research Campus
Loren L. Looger: Janelia Research Campus
Baljit S. Khakh: Department of Physiology, David Geffen School of Medicine, University of California Los Angeles

DOI: https://doi.org/10.1038/s41467-019-08441-5
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

ATP has essential roles in cell signalling and energy homeostasis and biosensors to detect it have many potential applications. Here, the authors develop a new ATP sensor that can be targeted to the membrane or cytosol.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal