Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

I-Na Lu; Celia Dobersalske; Laurèl Rauschenbach; Sarah Teuber-Hanselmann; Anita Steinbach; Vivien Ullrich; Shruthi Prasad; Tobias Blau; Sied Kebir; Jens T. Siveke; Jürgen C. Becker; Ulrich Sure; Martin Glas; Björn Scheffler; Igor Cima

doi:10.1038/s41467-021-23995-z

Nature Communications (Jun 2021)

Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression

I-Na Lu,
Celia Dobersalske,
Laurèl Rauschenbach,
Sarah Teuber-Hanselmann,
Anita Steinbach,
Vivien Ullrich,
Shruthi Prasad,
Tobias Blau,
Sied Kebir,
Jens T. Siveke,
Jürgen C. Becker,
Ulrich Sure,
Martin Glas,
Björn Scheffler,
Igor Cima

Affiliations

I-Na Lu: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Celia Dobersalske: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Laurèl Rauschenbach: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Sarah Teuber-Hanselmann: Institute of Neuropathology, University Hospital Essen
Anita Steinbach: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Vivien Ullrich: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Shruthi Prasad: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Tobias Blau: Institute of Neuropathology, University Hospital Essen
Sied Kebir: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Jens T. Siveke: German Cancer Research Center (DKFZ)
Jürgen C. Becker: German Cancer Research Center (DKFZ)
Ulrich Sure: German Cancer Consortium (DKTK)
Martin Glas: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Björn Scheffler: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen
Igor Cima: DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen

DOI: https://doi.org/10.1038/s41467-021-23995-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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A deeper knowledge of the immune cell profile within the brain cancer tumor microenvironment (TM) could identify targets to improve immunotherapy efficacy. Here, in glioblastoma, the authors find haematopoietic stem and progenitor cells in the TM, which are associated with poor prognosis and increased immunosuppression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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