Behaviour of Disc Oedema During and After Amiodarone Optic Neuropathy: Case Report

Abstract

A 73-year-old woman with atrial fibrillation treated with Amiodarone presented with Optic Disc oedema in right eye (OD). Using Optical Coherence Tomography (OCT) we describe the impact of this neuropathy on Retinal Nerve Fibre Layer (RNFL). At diagnosis RNFL average was of 188 µm OD and 77 µm in the left eye (OS), six months after discontinuation of the drug decreased to 40 µm in OD and 76 µm in OS. The RNFL average of OD presented a transient increase during the acute oedema that returned to normal levels during the first month after discontinuation of the drug and fell dramatically to 44 µm at the second month and 40 µm at the sixth month. We show there is axonal loss after amiodaroneassociated optic neuropathy measured with OCT. The OCT may be used in these patients to document changes in RNFL in the follow-up.

Keywords

• optic coherence tomography
• optic atrophy
• toxic neuropathy