Nature Communications (Jan 2019)
A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens
- Xiao Luo,
- Liujia Qian,
- Yansheng Xiao,
- Yao Tang,
- Yang Zhao,
- Xia Wang,
- Luyan Gu,
- Zuhai Lei,
- Jianming Bao,
- Jiahui Wu,
- Tingting He,
- Fupin Hu,
- Jing Zheng,
- Honglin Li,
- Weiping Zhu,
- Lei Shao,
- Xiaojing Dong,
- Daijie Chen,
- Xuhong Qian,
- Youjun Yang
Affiliations
- Xiao Luo
- State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
- Liujia Qian
- School of Pharmacy, Shanghai Jiao Tong University
- Yansheng Xiao
- Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
- Yao Tang
- Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
- Yang Zhao
- Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
- Xia Wang
- Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
- Luyan Gu
- Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
- Zuhai Lei
- Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
- Jianming Bao
- State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry
- Jiahui Wu
- State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry
- Tingting He
- Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology
- Fupin Hu
- Institute of Antibiotics, Huashan Hospital, Fudan University
- Jing Zheng
- Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
- Honglin Li
- Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
- Weiping Zhu
- State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
- Lei Shao
- State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry
- Xiaojing Dong
- State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry
- Daijie Chen
- School of Pharmacy, Shanghai Jiao Tong University
- Xuhong Qian
- State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
- Youjun Yang
- State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-018-08241-3
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Preparation of xanthene-containing compounds has been limited due to structural bias existing methods pose. Here, the authors developed a mild, diversity-oriented method for rhodamines synthesis, leading to the finding of compounds with antibacterial potency against a variety of bacterial species.
