Features of Some Hormonal Parameters in Patients with Perinatal Losses

Abstract

The presence of mixed urogenital infections during pregnancy leads to violations in mother’s body: changes of homeostasis, depression of the immune response, induction of the autoimmune processes resulting in reduced resistance to infectious agents and enhancement of pathological effects on the fetus, which greatly increases the risk of adjustment disorders in a newborn. The objective of this study was to investigate some indicators of homeostasis in patients with a history of perinatal losses.184 pregnant women with perinatal losses at the age of 19–34 years were under observation. Study group consisted of 110 pregnant women examined and treated according to the developed scheme, comparison group — of 74 pregnant women examined and treated according to a standard scheme. Control group made up 30 apparently healthy pregnant women. The study of hormonal status was carried out by determining estriol, progesterone, cortisol, placental lactogen using radioimmunoassay method by means of commercial kits ESA-IRE-Soring (France) as per proposed instructions. The results of the study allowed us to make the conclusion that at the initial forms of fetoplacental insufficiency, values of the enzymes activity may be prognostic markers of its violation. Adverse background due to infection affects the adequate production of hormones and enzymes.

Keywords

• homeostasis
• perinatal losses