Global Insights and Key Trends in Gut Microbiota Research for Premature Infants: A Bibliometric and Visualization Study

Abstract

Juanzhi Yang,1 Huanxia Qu,2 Qi Liu,1 Yixing Wang,1 Jiaxin Cao,1 Feng Jiang,3 Qian Wang,4 Jin Shu1 1Department of Pediatrics, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Blood Transfusion, Zhenjiang First People’s Hospital, Zhenjiang, People’s Republic of China; 3Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People’s Republic of China; 4Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Jin Shu, Department of Pediatrics, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, 212008, People’s Republic of China, Email [email protected] Feng Jiang, Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, 200011, People’s Republic of China, Email [email protected]: Premature infants, defined as those born before 37 weeks of gestation, face numerous health challenges due to their underdeveloped systems. One critical aspect of their health is the gut microbiota, which plays a vital role in their immune function and overall development. This study provides a comprehensive bibliometric analysis of research trends, influential contributors, and evolving themes in the study of gut microbiota in premature infants over the past two decades.Methods: We conducted a bibliometric analysis using the Web of Science Core Collection database, covering publications from January 1, 2004, to June 17, 2024. We employed VOSviewer, the R package “bibliometrix”, and Citespace for data visualization and analysis, focusing on co-authorship, co-citation, and keyword co-occurrence networks.Results: The temporal analysis revealed a significant increase in research output on gut microbiota in premature infants, particularly in the last decade. Early research primarily focused on characterizing the gut microbiota of premature infants, identifying less diversity and a higher prevalence of pathogenic bacteria compared to full-term infants. Key research themes identified include probiotics, necrotizing enterocolitis (NEC), and breastfeeding. Probiotic studies highlighted the potential of strains like Bifidobacterium and Lactobacillus in reducing NEC and sepsis incidences. Breastfeeding research consistently showed the benefits of human milk in fostering a healthier gut microbiota profile. Co-authorship and co-citation analyses identified key contributors and influential studies, emphasizing strong international collaborations, particularly among researchers from the United States, China, and European countries.Conclusion: This bibliometric analysis underscores the growing recognition of the gut microbiota’s crucial role in the health of premature infants. The field has seen significant advancements, particularly in understanding how interventions like probiotics and breastfeeding can modulate gut microbiota to improve health outcomes. Continued research and international collaboration are essential to further unravel the complexities of gut microbiota in premature infants and develop effective therapeutic strategies.Keywords: premature infants, gut microbiota, web of science, bibliometric analysis

Keywords

• premature infants
• gut microbiota
• web of science
• bibliometric analysis