Медицинская иммунология (Jul 2014)

GENETIC FACTORS INDUCING DISTURBED REGULATION OF ANGIOGENESIS IN DIABETES MELLITUS TYPE 2

  • V. I. Konenkov,
  • A. V. Shevchenko,
  • V. F. Prokof’ev,
  • V. V. Klimontov,
  • M. A. Korolev,
  • O. N. Fazulina,
  • S. A. Lapsina,
  • E. A. Koroleva

DOI
https://doi.org/10.15789/1563-0625-2012-6-489-500
Journal volume & issue
Vol. 14, no. 6
pp. 489 – 500

Abstract

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Abstract. The article includes results of studying frequency distributions of polymorphic genotypes forsome genes regulating angiogenesis, i.e., MMP and VEGF, and their combinations with genotypes of some cytokines showing pro-angiogenic activity in patients with diabetes mellitus type 2 (DM2) and healthy controls. Angiogenesis-inducing MMP2-MMP9-VEGF genotype constellations have been shown to be more common in DM patients, thus presumably causing an imbalance between activation and suppression signals, being connected with C alleles of VEGF and MMP2, as well as with harboring of MMP9 C allele. Certain genotypes of IL-1B, IL-4, IL-10, IL-6, and TNFA, along with MMP and VEGF variants are more common within combined genetic patterns in DM patients. It is suggested that allelic combination studies of angiogenesis- and inflammation-regulating genes are necessary for understanding the DM2 pathogenesis, taking into account genetic control mechanisms influencing basic production levels of these regulatory factors.

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