Boğaziçi Tıp Dergisi (Mar 2023)

The Effects of Inhaled Corticosteroids on Bone Mineral Density, Bone Formation/Resorption Markers, and Quality of Life in Premenopausal Asthmatic Women

  • Arzu Atıcı,
  • Lale Cerrahoğlu,
  • Pınar Çelik,
  • Bekir Sami Uyanık

DOI
https://doi.org/10.14744/bmj.2022.33254
Journal volume & issue
Vol. 10, no. 1
pp. 13 – 18

Abstract

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INTRODUCTION: We aimed to investigate the effects of inhaled corticosteroids (CS) on bone mineral density (BMD), bone formation-resorption markers, and quality of life in premenopausal asthmatic women. METHODS: Premenopausal women diagnosed with asthma and using regular inhaled CS for at least 3 months were included in our cross-sectional study. As the control group, premenopausal women without a diagnosis of asthma and who had not used steroid before were included in the study. Serum bone-specific alkaline phosphatase (BAP), osteocalcin, and β crosslapse levels were evaluated as bone formation-resorption markers. BMD, T and Z scores of lumbar vertebra L2-L4 anterior, left femoral neck, and total hip were measured. The Short Form 36 (SF-36) quality of life scale was used to assess the quality of life. RESULTS: Twenty-two asthmatic patients and 22 non-asthmatic individuals as a control group were included in the study. There was no statistically significant difference between L2-L4 anterior, femoral neck and total hip BMD, T and Z scores, and serum osteocalcin, β crosslaps, and BAP levels between both groups (p>0.05). No statistically significant correlation was found between the duration of inhaled CS use, cumulative inhaled CS dose, and BMD in asthmatic patients (p>0.05). SF-36 quality of life scale pain score was found to be statistically significantly higher in patients with asthma compared to the control group (p<0.05). No significant difference was found in the other subscales of the SF-36 quality of life scale (p>0.05). DISCUSSION AND CONCLUSION: In our study, we did not find the effect of inhaled CS on BMD and bone formation and resorption markers. We did not find any difference between the asthmatic patients and the control group in the sub-parameters of the SF-36 quality of life scale, except for pain. This suggests that inhaled CS may have a positive effect on quality of life in patients with asthma.

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