Emerging Infectious Diseases (Oct 2024)

Circovirus Hepatitis in Immunocompromised Patient, Switzerland

  • Baptiste Hamelin,
  • Philippe Pérot,
  • Ian Pichler,
  • Jasmin D. Haslbauer,
  • David Hardy,
  • David Hing,
  • Sarra Loulizi,
  • Béatrice Regnault,
  • Anouk Pieters,
  • Ingmar Heijnen,
  • Caroline Berkemeier,
  • Maria Mancuso,
  • Verena Kufner,
  • Niels Willi,
  • Anne Jamet,
  • Nolwenn Dheilly,
  • Marc Eloit,
  • Mike Recher,
  • Michael Huber,
  • Kirsten D. Mertz

DOI
https://doi.org/10.3201/eid3010.240678
Journal volume & issue
Vol. 30, no. 10
pp. 2140 – 2144

Abstract

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We identified a novel human circovirus in an immunocompromised 66-year-old woman with sudden onset of self-limiting hepatitis. We detected human circovirus 1 (HCirV-1) transcripts in hepatocytes and the HCirV-1 genome long-term in the patient’s blood, stool, and urine. HCirV-1 is an emerging human pathogen that persists in susceptible patients.

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