Effect of tenofovir Administration And Withdrawl On The Kidney Tissues Of Adult Male Albino Rats And The Protective Role Of Vitamin E

Abstract

Tenofovir disoproxil fumarate is one of antiretroviral drugs used to treat chronic hepatitis B and HIV. In recent studies many Tenofovir problems were recorded; acute kidney injury (AKI), chronic kidney diseases (CKD) and Fanconi syndrome. Vitamin E is a powerful antioxidant that reduce free radical damage. Vitamin E supplementation can protect kidney tissues and enhances their regeneration if it is added to Tenofovir treatment. The aim of the present study is to describe the changes which occur in the kidney tissues of the adult male albino rats after Tenofovir administration and determine whether these changes are reversible or not after drug withdrawal, Also, whether vitamin E has a protective role or not. A total number of 40 adult male albino rats weighting 200-250 grams were used. Rats were divided into four groups, 10 rats in each group. The first group I (control group), The second group II which was treated with Tenofovir 10 mg/kg/day for two months, the third group III which was treated with Tenofovir10 mg/kg/day for two months, vitamin E also was given 100mg/kg/day for two months. The fourth group IV which was treated with Tenofovir 10 mg/kg/day for two months then withdrawal of Tenofovir for one month. There was marked degeneration of renal glomeruli and tubules in group II which was highly statistically significant than control group (P< 0.001), while in group III there was marked improvement of renal glomeruli and tubules which was highly statistically significant than group II (P<0.001). while in group IV these changes were moderately significant when compared with group II (P<0.01). Therefore, Vitamin E has a protective role if it is added to Tenofovir treatment, also vitamin E enhances regeneration of renal tissues after Tenofovir withdrawal.

Keywords

• tenofovir
• kidney
• fanconi syndrome
• vitamin e