Journal of Mazandaran University of Medical Sciences (Jan 2007)
The Recurrence Rate of Helicobacter Pylori Infection 2 Years After Eradication
Abstract
Background and purpose: Helicobacter pylori(HP) has an important role in the pathogenesis of gastritis, peptic ulcer and gastric cancer. The eradication of HP results in the prevention of the recurrence of peptic ulcer and its complications. In developed countries, the recurrence of infection is unusual and rare after the successful eradication of HP infection, however it is likely in developing countries and the rate is variable in different parts of the world. The aim of this study was to evaluate the recurrence rate of HP infection, at least 2 years after the successful eradication of HP infection.Materials and Methods: Those patients with documented duodenal ulcer (according to endoscopy) and HP infection (according to rapid urease test) were included in this study. The patients were treated with different HP eradication regimens and the eradication was proved, using the 14C Urea Breathing Test (UBT). The patients were re-evaluated with 14C UBT at least 2 years after the first negative UBT result (mean duration: 36 months, ranging from 24 to 30 months).Results: Eighty patients (51 males and 29 females) were included in the study. Mean age was 40.53 + 10.99 years (ranging from 20 to 79 years). HP infection recurrence was documented in 11 patients (13.75%).Conclusion: Although HP eradication was performed successfully, the recurrence rate was significant. This can influence the therapeutic and the following up strategies of the patients.
