Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Bin Tu; Bin Tu; Yanrong Gao; Yanrong Gao; Feifei Sun; Feifei Sun; Mingjie Shi; Yongzhuo Huang; Yongzhuo Huang; Yongzhuo Huang; Yongzhuo Huang; Yongzhuo Huang

doi:10.3389/fphar.2022.840440

Frontiers in Pharmacology (Mar 2022)

Lipid Metabolism Regulation Based on Nanotechnology for Enhancement of Tumor Immunity

Bin Tu,
Bin Tu,
Yanrong Gao,
Yanrong Gao,
Feifei Sun,
Feifei Sun,
Mingjie Shi,
Yongzhuo Huang,
Yongzhuo Huang,
Yongzhuo Huang,
Yongzhuo Huang,
Yongzhuo Huang

Affiliations

Bin Tu: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Bin Tu: University of Chinese Academy of Sciences, Beijing, China
Yanrong Gao: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yanrong Gao: University of Chinese Academy of Sciences, Beijing, China
Feifei Sun: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Feifei Sun: School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China
Mingjie Shi: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yongzhuo Huang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Yongzhuo Huang: University of Chinese Academy of Sciences, Beijing, China
Yongzhuo Huang: Zhongshan Institute for Drug Discovery, SIMM, CAS, Zhongshan, China
Yongzhuo Huang: NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients, Shanghai, China
Yongzhuo Huang: School of Advanced Study, Institute of Natural Medicine and Health Product, Taizhou University, Taizhou, China

DOI: https://doi.org/10.3389/fphar.2022.840440
Journal volume & issue: Vol. 13

Abstract

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The hallmarks of cancer include dysregulated metabolism and immune evasion. As a basic way of metabolism, lipid metabolism is reprogrammed for the rapid energy and nutrient supply in the occurrence and development of tumors. Lipid metabolism alterations that occur in the tumor microenvironment (TME) affect the antitumor responses of immune cells and cause immune evasion. Therefore, targeting lipid metabolism in the TME for enhancing the antitumor effect of immune cells is a promising direction for cancer treatment. Cancer nanomedicine has great potential in regulating tumor metabolism and tumor immunity. This review summarizes the nanotechnology-based strategies for lipid metabolism regulation in the TME for enhanced anticancer immune responses.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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