Single-cell analysis of diverse immune phenotypes in malignant pleural effusion

Zhong-Yin Huang; Ming-Ming Shao; Jian-Chu Zhang; Feng-Shuang Yi; Juan Du; Qiong Zhou; Feng-Yao Wu; Sha Li; Wei Li; Xian-Zhen Huang; Kan Zhai; Huan-Zhong Shi

doi:10.1038/s41467-021-27026-9

Nature Communications (Nov 2021)

Single-cell analysis of diverse immune phenotypes in malignant pleural effusion

Zhong-Yin Huang,
Ming-Ming Shao,
Jian-Chu Zhang,
Feng-Shuang Yi,
Juan Du,
Qiong Zhou,
Feng-Yao Wu,
Sha Li,
Wei Li,
Xian-Zhen Huang,
Kan Zhai,
Huan-Zhong Shi

Affiliations

Zhong-Yin Huang: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University
Ming-Ming Shao: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University
Jian-Chu Zhang: Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Feng-Shuang Yi: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University
Juan Du: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University
Qiong Zhou: Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Feng-Yao Wu: Department of Tuberculosis, Nanning Fourth People’s Hospital
Sha Li: Department of Tuberculosis, Nanning Fourth People’s Hospital
Wei Li: Department of Tuberculosis, Nanning Fourth People’s Hospital
Xian-Zhen Huang: Department of Tuberculosis, Nanning Fourth People’s Hospital
Kan Zhai: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University
Huan-Zhong Shi: Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University

DOI: https://doi.org/10.1038/s41467-021-27026-9
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Detailed immune cell subset identification in human lung (malignant pleural effusion) MPE is important for diagnosis and prognosis. Here the authors use single cell RNA sequencing to identify immune cell types within MPE and show differential gene expression compared to circulating immune cells in blood.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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