Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene

Chika Saegusa; Hideki Mutai; Tsubasa Saeki; Saeko Matsuzaki; Akifumi Mizukoshi; Shin-ichiro Kitajiri; Tatsuo Matsunaga; Makoto Hosoya; Hideyuki Okano; Masato Fujioka

Stem Cell Research (Sep 2024)

Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene

Chika Saegusa,
Hideki Mutai,
Tsubasa Saeki,
Saeko Matsuzaki,
Akifumi Mizukoshi,
Shin-ichiro Kitajiri,
Tatsuo Matsunaga,
Makoto Hosoya,
Hideyuki Okano,
Masato Fujioka

Affiliations

Chika Saegusa: Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
Hideki Mutai: Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan
Tsubasa Saeki: Department of Physiology, Keio University School of Medicine, Tokyo, Japan
Saeko Matsuzaki: Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
Akifumi Mizukoshi: Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Otolaryngology, Kyoto Katsura Hospital, Kyoto, Japan
Shin-ichiro Kitajiri: Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
Tatsuo Matsunaga: Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan; Medical Genetics Center, NHO Tokyo Medical Center, Tokyo, Japan
Makoto Hosoya: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
Hideyuki Okano: Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Keio University Regenerative Medicine Research Center, Kanagawa, Japan; Division of CNS Regeneration and Drug Discovery, International Center for Brain Science, Fujita Health University, Aichi, Japan; Corresponding authors.
Masato Fujioka: Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan; Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan; Corresponding authors.

Journal volume & issue: Vol. 79
p. 103489

Abstract

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Disease-related cells differentiated from patient-derived iPSCs are useful for elucidating the pathophysiological mechanisms underlying these diseases. In this study, four iPSC lines were established from independent patients with sensorineural hearing loss and a mutation in EYA4. These iPSCs showed pluripotency, the capacity to differentiate into three germ layers, and normal karyotypes, suggesting that these lines are useful for the pathological study of sensorineural hearing loss and drug screening for ear disorders.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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