Tarlatamab for Large Cell Neuroendocrine Carcinoma in a Young Adult: A Case Report

Shetal A. Patel, MD, PhD; Young Whang, MD, PhD; Chaely Medley, NP; Kevin Chen, PharmD; Jasmine Jordan, BS; Dante Bortone, PhD; Benjamin Vincent, MD, PhD; Jared Weiss, MD

JTO Clinical and Research Reports (Oct 2024)

Tarlatamab for Large Cell Neuroendocrine Carcinoma in a Young Adult: A Case Report

Shetal A. Patel, MD, PhD,
Young Whang, MD, PhD,
Chaely Medley, NP,
Kevin Chen, PharmD,
Jasmine Jordan, BS,
Dante Bortone, PhD,
Benjamin Vincent, MD, PhD,
Jared Weiss, MD

Affiliations

Shetal A. Patel, MD, PhD: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Young Whang, MD, PhD: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Chaely Medley, NP: Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Kevin Chen, PharmD: Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, North Carolina
Jasmine Jordan, BS: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Dante Bortone, PhD: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Benjamin Vincent, MD, PhD: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Jared Weiss, MD: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Corresponding author. Address for correspondence: Jared Weiss, MD, Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Chapel Hill, NC 27599.

Journal volume & issue: Vol. 5, no. 10
p. 100712

Abstract

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A 20-year-old man with metastatic large cell neuroendocrine carcinoma of the lung was treated with the delta-like ligand 3–targeting bispecific T cell engager, tarlatamab. Treatment was complicated by transient cytokine release syndrome but resulted in a partial response. Bispecific T cell engagers may offer a novel treatment approach for large cell neuroendocrine carcinoma of the lung.

Published in JTO Clinical and Research Reports

ISSN: 2666-3643 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/jto-clinical-and-research-reports/

About the journal

Abstract

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