LncRNA DANCR and miR-320a suppressed osteogenic differentiation in osteoporosis by directly inhibiting the Wnt/β-catenin signaling pathway

Abstract

Osteoporosis: Tiny targets to keep bones strong Two non-coding RNAs are potential targets for reducing bone loss in post-menopausal osteoporosis. Bones are constantly being remodeled; when resorption outpaces generation of new bone, bones are weakened, causing osteoporosis and leading to decreased quality of life and injuries. Although treatments exist, they often have undesirable side effects, and new treatments are needed. The molecular basis of the changes that accompany osteoporosis are poorly understood. Da Zhong at the Xiangya Hospital of Central South University in Changsha, China, and co-workers investigated how two non-coding RNAs, small molecules that regulate gene expression, are involved in the progression of post-menopausal osteoporosis. They found that levels of both molecules are increased in osteoporosis, and that silencing them increases building of new bone, key to maintaining bone strength. These results illuminate a potential new direction in treatments for osteoporosis.