Nature Communications (Nov 2022)

Flash drug release from nanoparticles accumulated in the targeted blood vessels facilitates the tumour treatment

  • Ivan V. Zelepukin,
  • Olga Yu. Griaznova,
  • Konstantin G. Shevchenko,
  • Andrey V. Ivanov,
  • Ekaterina V. Baidyuk,
  • Natalia B. Serejnikova,
  • Artur B. Volovetskiy,
  • Sergey M. Deyev,
  • Andrei V. Zvyagin

DOI
https://doi.org/10.1038/s41467-022-34718-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Achieving the delivery of drugs into the centre of solid tumours is a challenge due to the tumour micro-environment. Here, the authors propose a system for using the rapid release of large quantities of drug inside tumour microcapillaries for the gradient-driven diffusion of drugs into solid tumours.