Factors related to lymph node metastasis in Siewert type Ⅲ carcinoma of esophagogastric junction

Abstract

Objective To investigate the influencing factors for lymph node metastasis in Siewert type Ⅲ carcinoma of esophagogastric junction. Methods A total of 162 patients with Siewert type Ⅲ carcinoma of esophagogastric junction undergoing radical surgery in our department of general surgery from January 2010 to June 2018 were recruited in this study. Their clinical and pathological data were collected and retrospectively analyzed for independent influencing factors for lymph node metastasis. Results Among the 162 patients with Siewert type Ⅲ carcinoma of esophagogastric junction, lymph node metastases were found in 72 cases, with a metastatic rate of 44.4%. Multivariate logistic regression analysis showed that the pathological types of tumor, histological differentiation grade, depth of invasion and presence or absence of vascular tumor thrombus were independent risk factors for lymph node metastasis (P < 0.05). Conclusion The Siewert type Ⅲ carcinoma of esophagogastric junction is more prone to lymph node metastasis in signet ring cell carcinoma, low-grade differentiation, invasion to full-thickness gastric wall and vascular tumor thrombus.

Keywords

• esophagogastric junction carcinoma
• lymph node metastasis
• risk factors