Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella

Hsu-Ming Chung; Wei-Hsien Wang; Tsong-Long Hwang; Jan-Jung Li; Lee-Shing Fang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/molecules190812320

Molecules (Aug 2014)

Rumphellaones B and C, New 4,5-Seco-Caryophyllane Sesquiterpenoids from Rumphella

Hsu-Ming Chung,
Wei-Hsien Wang,
Tsong-Long Hwang,
Jan-Jung Li,
Lee-Shing Fang,
Yang-Chang Wu,
Ping-Jyun Sung

Affiliations

Hsu-Ming Chung: Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
Wei-Hsien Wang: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Jan-Jung Li: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Lee-Shing Fang: Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Yang-Chang Wu: School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Ping-Jyun Sung: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan

DOI: https://doi.org/10.3390/molecules190812320
Journal volume & issue: Vol. 19, no. 8
pp. 12320 – 12327

Abstract

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Two new 4,5-seco-caryophyllane sesquiterpenoids, rumphellaones B (1) and C (2), which were found to possess unprecedented γ-lactone moieties, were obtained from the gorgonian coral Rumphella antipathies. The structures of 1 and 2 were elucidated by spectroscopic methods and compound 2 was found to display modest inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils at a concentration of 10 μg/mL

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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