Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Lap Kwan Chan; Miltiadis Tsesmelis; Melanie Gerstenlauer; Frank Leithäuser; Alexander Kleger; Lukas Daniel Frick; Harald Jacob Maier; Thomas Wirth

doi:10.1038/s42003-022-03371-3

Communications Biology (May 2022)

Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis

Lap Kwan Chan,
Miltiadis Tsesmelis,
Melanie Gerstenlauer,
Frank Leithäuser,
Alexander Kleger,
Lukas Daniel Frick,
Harald Jacob Maier,
Thomas Wirth

Affiliations

Lap Kwan Chan: Institute of Physiological Chemistry, University of Ulm
Miltiadis Tsesmelis: Institute of Physiological Chemistry, University of Ulm
Melanie Gerstenlauer: Institute of Physiological Chemistry, University of Ulm
Frank Leithäuser: Institute of Pathology, University Hospital of Ulm
Alexander Kleger: Department of Internal Medicine I, University Hospital of Ulm
Lukas Daniel Frick: Department of Pathology and Molecular Pathology, University Hospital of Zurich
Harald Jacob Maier: Institute of Physiological Chemistry, University of Ulm
Thomas Wirth: Institute of Physiological Chemistry, University of Ulm

DOI: https://doi.org/10.1038/s42003-022-03371-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 16

Abstract

Read online

A model of autoimmune pancreatitis is developed by blocking the activation of NF-κB in pancreatic stellate cells, via conditional deletion of NEMO (IKKγ), which presents strong pancreatic inflammation with eosinophilia after the induction of chronic pancreatitis by repeated caerulein challenges.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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