Nature Communications (Oct 2019)
Microbe-host interplay in atopic dermatitis and psoriasis
- Nanna Fyhrquist,
- Gareth Muirhead,
- Stefanie Prast-Nielsen,
- Marine Jeanmougin,
- Peter Olah,
- Tiina Skoog,
- Gerome Jules-Clement,
- Micha Feld,
- Mauricio Barrientos-Somarribas,
- Hanna Sinkko,
- Ellen H. van den Bogaard,
- Patrick L.J.M. Zeeuwen,
- Gijs Rikken,
- Joost Schalkwijk,
- Hanna Niehues,
- Walter Däubener,
- Silvia Kathrin Eller,
- Helen Alexander,
- Davide Pennino,
- Sari Suomela,
- Ioannis Tessas,
- Emilia Lybeck,
- Anna M. Baran,
- Hamid Darban,
- Roopesh Singh Gangwar,
- Ulrich Gerstel,
- Katharina Jahn,
- Piia Karisola,
- Lee Yan,
- Britta Hansmann,
- Shintaro Katayama,
- Stephan Meller,
- Max Bylesjö,
- Philippe Hupé,
- Francesca Levi-Schaffer,
- Dario Greco,
- Annamari Ranki,
- Jens M. Schröder,
- Jonathan Barker,
- Juha Kere,
- Sophia Tsoka,
- Antti Lauerma,
- Vassili Soumelis,
- Frank O. Nestle,
- Bernhard Homey,
- Björn Andersson,
- Harri Alenius
Affiliations
- Nanna Fyhrquist
- Institute of Environmental Medicine, Karolinska Institutet
- Gareth Muirhead
- Department of Informatics, Faculty of Natural and Mathematical Sciences, King’s College London
- Stefanie Prast-Nielsen
- Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet
- Marine Jeanmougin
- Institut Curie
- Peter Olah
- Department of Dermatology, University Hospital Duesseldorf
- Tiina Skoog
- Department of Biosciences and Nutrition, Karolinska Institutet
- Gerome Jules-Clement
- Institut Curie
- Micha Feld
- Department of Dermatology, University Hospital Duesseldorf
- Mauricio Barrientos-Somarribas
- Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet
- Hanna Sinkko
- Institute of Environmental Medicine, Karolinska Institutet
- Ellen H. van den Bogaard
- Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Patrick L.J.M. Zeeuwen
- Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Gijs Rikken
- Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Joost Schalkwijk
- Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Hanna Niehues
- Department of Dermatology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences
- Walter Däubener
- Institute for Medical Microbiology and Hospital Hygiene, Heinrich Heine University Duesseldorf
- Silvia Kathrin Eller
- Institute for Medical Microbiology and Hospital Hygiene, Heinrich Heine University Duesseldorf
- Helen Alexander
- St John’s Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, Kings College London
- Davide Pennino
- Cutaneous Medicine Unit, St. John’s Institute of Dermatology and Biomedical Research Centre, Faculty of Life Sciences and Medicine, King’s College London
- Sari Suomela
- Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Hospital, Inflammation Centre
- Ioannis Tessas
- Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Hospital, Inflammation Centre
- Emilia Lybeck
- Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Hospital, Inflammation Centre
- Anna M. Baran
- Department of Dermatology, University Hospital Duesseldorf
- Hamid Darban
- Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet
- Roopesh Singh Gangwar
- Pharmacology Unit, School of Pharmacy, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem
- Ulrich Gerstel
- Department of Dermatology, University Hospital Schleswig-Holstein
- Katharina Jahn
- Department of Dermatology, University Hospital Duesseldorf
- Piia Karisola
- Department of Bacteriology and Immunology, Medicum, University of Helsinki
- Lee Yan
- Department of Informatics, Faculty of Natural and Mathematical Sciences, King’s College London
- Britta Hansmann
- Department of Dermatology, University Hospital Schleswig-Holstein
- Shintaro Katayama
- Department of Biosciences and Nutrition, Karolinska Institutet
- Stephan Meller
- Department of Dermatology, University Hospital Duesseldorf
- Max Bylesjö
- Fios Genomics
- Philippe Hupé
- Institut Curie
- Francesca Levi-Schaffer
- Pharmacology Unit, School of Pharmacy, The Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem
- Dario Greco
- Faculty of Medicine and Life Sciences, University of Tampere
- Annamari Ranki
- Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Hospital, Inflammation Centre
- Jens M. Schröder
- Department of Dermatology, University Hospital Schleswig-Holstein
- Jonathan Barker
- St John’s Institute of Dermatology, Division of Genetics and Molecular Medicine, Faculty of Life Sciences and Medicine, Kings College London
- Juha Kere
- Department of Biosciences and Nutrition, Karolinska Institutet
- Sophia Tsoka
- Department of Informatics, Faculty of Natural and Mathematical Sciences, King’s College London
- Antti Lauerma
- Department of Dermatology, Allergology and Venereology, University of Helsinki and Helsinki University Hospital, Inflammation Centre
- Vassili Soumelis
- Institut Curie
- Frank O. Nestle
- Cutaneous Medicine Unit, St. John’s Institute of Dermatology and Biomedical Research Centre, Faculty of Life Sciences and Medicine, King’s College London
- Bernhard Homey
- Department of Dermatology, University Hospital Duesseldorf
- Björn Andersson
- Department of Cell and Molecular Biology, Science for Life Laboratory, Karolinska Institutet
- Harri Alenius
- Institute of Environmental Medicine, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-019-12253-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Atopic dermatitis (AD) and psoriasis (PSO) are associated with dysbiosis. Here, by analyses of skin microbiome and host transcriptome of AD and PSO patients, the authors find distinct microbial and disease-related gene transcriptomic signatures that differentiate both diseases.
