Nature Communications (Mar 2022)
An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis
Abstract
HitRS is a two-component system that responds to cell envelope damage in the bacterium Bacillus anthracis. Here, the authors identify an RNA-binding protein that regulates HitRS function by modulating the stability of the hitRS mRNA. In addition, the protein binds to over 70 RNAs and affects the expression of genes involved in multiple cellular processes.