New methods in meningitis diagnosis

Abstract

Meningitis remains a worldwide problem and Central nervous system (CNS) infections are associated with devastating sequelae, including cognitive deficits, vision and hearing impairment, motor and sensory deficits and epilepsy in over one-half of survivors. Rapid diagnosis of meningitis is essential to improve chances at survival and minimize unnecessary healthcare costs related to isolation procedures and empiric treatment. Multiplex molecular assays are an attractive option for the simultaneous detection of several microbial targets. Currently, several assays are marketed. The aim of our review is to comprehensively evaluate the molecular available systems of using a new multiplex PCR panel in determining the microbiologic etiologies of meningitis.

Keywords

• meningitis
• molecular biology
• infectious disease