The Comparison of the Effects of “Trometamol; Tris- Hydroxymethylaminomethane” and “Sodium Bicarbonate” Treatments on Mortality and Survival Time in Experimental Metabolic Acidosis Induced by Methanol Intoxication

Abstract

Aim: Metabolic acidosis is the most serious complication of methanol intoxication, which needs urgent treatment. The aim of this study was to investigate effects of “Trometamol; Tris-hydroxymethylaminomethane” (THAM) and “Sodium Bicarbonate” (NaHCO3) treatments on mortality and survival time in rats with metabolic acidosis induced by intragastric-administered methanol.Materials and Methods: In 21 rats, a cannula was inserted in the right common carotid artery; the esophagus of each rat was penetrated with a branul. Baseline arterial blood gas samples were taken, and a 6 g/kg dose of methanol was injected into the cannula in the esophagus. The rats with confirmed acidosis were separated into three groups as “THAM,” “NaHCO3,” and “control” for the treatments. The control group received no medication, and the THAM and NaHCO3 groups were administered corresponding treatments intravenously.Results: A statistically significant difference was determined between the survival times of the THAM and NaHCO3 groups (p=0.036) and the THAM and control groups (p=0.002).Conclusion: The results of this study support the use of THAM, which is a biological, low-toxicity, inert amino alcohol, instead of NaHCO3 in the treatment of metabolic acidosis induced by intragastric methanol intoxication.

Keywords

• Metabolic acidosis
• methanol
• Tris-hydroxymethylaminomethane
• sodium bicarbonate
• rat