Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study

Sijie Zhang; Aijun Liao; Yujue Wang; Qian Liu; Lijun Ouyang; Huiqing Peng; Liu Yuan; Linlin Zhao; Xinbo Yang; Xiaogang Chen; Ying He; Zongchang Li

doi:10.1038/s41537-024-00510-z

Schizophrenia (Sep 2024)

Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study

Sijie Zhang,
Aijun Liao,
Yujue Wang,
Qian Liu,
Lijun Ouyang,
Huiqing Peng,
Liu Yuan,
Linlin Zhao,
Xinbo Yang,
Xiaogang Chen,
Ying He,
Zongchang Li

Affiliations

Sijie Zhang: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Aijun Liao: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Yujue Wang: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Qian Liu: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Lijun Ouyang: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Huiqing Peng: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Liu Yuan: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Linlin Zhao: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Xinbo Yang: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Xiaogang Chen: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Ying He: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University
Zongchang Li: Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University

DOI: https://doi.org/10.1038/s41537-024-00510-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 5

Abstract

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Abstract Proximity barcoding assay, a high-throughput method for single-exosome analysis, was employed to profile surface proteins on individual exosomes of SCZ patients. This analysis identified five differentially expressed proteins (DEPs) between SCZ patients and healthy controls (HC) and six DEPs between antipsychotic responders and non-responders. Furthermore, two exosome clusters were found to be associated with SCZ, and certain DEPs were correlated with cognitive functions.

Published in Schizophrenia

ISSN: 2754-6993 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system: Psychiatry
Website: https://www.nature.com/npjschz/

About the journal