A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition

Mayo Kondo; Hirokazu Ogino; Hirohisa Ogawa; Tania Afroj; Yuko Toyoda; Satoshi Sakaguchi; Miki Tsuboi; Yoshimi Bando; Hisatsugu Goto; Koichi Tsuneyama; Yasuhiko Nishioka

Respiratory Medicine Case Reports (Jan 2018)

A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition

Mayo Kondo,
Hirokazu Ogino,
Hirohisa Ogawa,
Tania Afroj,
Yuko Toyoda,
Satoshi Sakaguchi,
Miki Tsuboi,
Yoshimi Bando,
Hisatsugu Goto,
Koichi Tsuneyama,
Yasuhiko Nishioka

Affiliations

Mayo Kondo: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Hirokazu Ogino: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Hirohisa Ogawa: Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Japan
Tania Afroj: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Yuko Toyoda: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Satoshi Sakaguchi: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Miki Tsuboi: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Yoshimi Bando: Division of Pathology, Tokushima University Hospital, Japan
Hisatsugu Goto: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan
Koichi Tsuneyama: Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Japan
Yasuhiko Nishioka: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Japan; Corresponding author. Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan.

Journal volume & issue: Vol. 25
pp. 119 – 121

Abstract

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A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because of obstructive pneumonia and end-stage renal disease, but the tumors progressed rapidly and resulted in death due to air obstruction by pharyngeal metastasis. The cancer was diagnosed as pleomorphic carcinoma in an autopsy. Viable lung tumor cells, which were resistant to radiotherapy, and the pharyngeal metastasis had mesenchymal phenotypes and expressed ZEB1 but not SNAI1. These observations indicated that ZEB1-associated epithelial-mesenchymal transition has malignant features including resistance to radiotherapy and aggressive metastatic potential. ZEB1-associated EMT may be an important mechanism to understand the pathophysiology of pleomorphic carcinoma. Keywords: Pulmonary pleomorphic carcinoma, Epithelial-mesenchymal transition (EMT), ZEB1

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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