Altered interhemispheric connectivity in Huntington’s Disease

Abstract

Pyramidal cells give rise to the corpus callosum, interhemispheric fibers that constitute the associations between the left and the right hemispheres. These interconnections are the substrates of important neurological functions, such as perception, memory, emotion, and movement control, which are all affected in Huntington’s disease (HD). In this study we used directional tract density patterns (dTDPs) to evaluate changes in interhemispheric connectivity in gene-expanded individuals, which included presymptomatic and early symptomatic HD subjects. Our results demonstrated regionally selective and progressive differences in dTDPs between distinct regions of the corpus callosum (subdivided by Hofer-Frahm scheme) in the gene-expanded cohorts. In the presymptomatic HD cohort, we found trends, such that the density of fibers was reduced in CC regions IIb, III, and IV (p < 0.05); fibers from these regions project to sensory, premotor, and motor cortical regions, respectively. In the HD cohort, we found reduction in the density of fibers in all CC regions, including in fibers extending to the cortical surface (p < 0.002). Our results support the use of dTDPs to evaluate individual and progressive changes in interhemispheric connectivity in HD.

Keywords

• Huntington’s Disease
• Human subjects
• Corpus callosum
• Interhemispheric connectivity
• Directional tract density patterns
• Diffusion magnetic resonance imaging