Interleukin-1β-gene polymorphisms in preeclamptic Egyptian women

Abstract

Aim of work: To investigate the relationship between IL-1β -31C/T (rs 1143627) and -11T/C (rs 16944) gene polymorphisms and preeclampsia. Patients and methods: Polymorphisms at -31C/T and -511T/C of IL-1β were genotyped using polymerase chain reaction restriction fragment length polymorphisms (PCR-RFLP). Results: Concerning results of interleukin-1β -31C/T, there were no statistically significant differences between the 2 studied groups regarding CC, CT or TT genotypes. Concerning -511T/C gene polymorphisms, there was statistically significant difference between the 2 studied groups regarding TT genotype, but there were no statistically significant differences between the 2 studied groups regarding CC or CT genotypes. Conclusion: To our knowledge, it is the first study to investigate the relationship between IL-1β gene polymorphisms and preeclampsia in Egyptian females.

Keywords

• In terleukin-1β -31C/T
• -511T/C
• Gene polymorphisms
• Preeclampsia