Nature Communications (Feb 2018)
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase
- Praveena S. Thiagarajan,
- Maksim Sinyuk,
- Soumya M. Turaga,
- Erin E. Mulkearns-Hubert,
- James S. Hale,
- Vinay Rao,
- Abeba Demelash,
- Caner Saygin,
- Arnab China,
- Tyler J. Alban,
- Masahiro Hitomi,
- Luke A. Torre-Healy,
- Alvaro G. Alvarado,
- Awad Jarrar,
- Andrew Wiechert,
- Valery Adorno-Cruz,
- Paul L. Fox,
- Benjamin C. Calhoun,
- Jun-Lin Guan,
- Huiping Liu,
- Ofer Reizes,
- Justin D. Lathia
Affiliations
- Praveena S. Thiagarajan
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Maksim Sinyuk
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Soumya M. Turaga
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Erin E. Mulkearns-Hubert
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- James S. Hale
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Vinay Rao
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Abeba Demelash
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Caner Saygin
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Arnab China
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Tyler J. Alban
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Masahiro Hitomi
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Luke A. Torre-Healy
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Alvaro G. Alvarado
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Awad Jarrar
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Andrew Wiechert
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Valery Adorno-Cruz
- Case Comprehensive Cancer Center
- Paul L. Fox
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Benjamin C. Calhoun
- Department of Pathology, Cleveland Clinic
- Jun-Lin Guan
- Department of Cancer Biology, University of Cincinnati
- Huiping Liu
- Case Comprehensive Cancer Center
- Ofer Reizes
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- Justin D. Lathia
- Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic
- DOI
- https://doi.org/10.1038/s41467-018-02938-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Connexin proteins are usually considered as tumor suppressors. Here, the authors show that connexin 26 (Cx26) regulates the self-renewal of breast cancer stem cells via a ternary complex with FAK and NANOG.
