Effect of Chronic Hyperglycemia on Cardiac Parasympathetic Functions in Type-2 Diabetes

Abstract

Objective: To evaluate effects of chronic hyperglycemia on cardiac parasympathetic functions in type 2 diabetics. Research Design and Methodology: HBA1c was estimated and Average Blood Glucose (ABG) was calculated in 100 type 2 diabetics fulfilling the study criteria, were subjected to cardiac parasympathetic function tests i.e. Resting Heart Rate(RHR), Heart Rate Variation to Deep Breathing (HRV) and Valsalva ratio. They were placed in two groups, group ‘A’ (n=60) diabetics with HbA1c 8% [ABG >180 mg/dl]. Results: The mean HbA1c of group A was 7.423% (SD±1.194), group B was 11.82% (SD±1.974). The ABG of group ‘A’ was 162.55 (SD±40.32), group ‘B’ was 316.8 (SD±79.25). RHR of group ‘A’ was 87.56 (SD±10.99), group ‘B’ was 93.09 (SD±14.07). The HRV of group ‘A’ was 19.5 (SD±9.76), group ‘B’ was 10.1 (SD±6.54). The Valsalva ratio of group ‘A” was 1.3244 (SD ± 0.1555), group ‘B’ was 0.06 (SD ± 0.0036). Conclusion: Current study evaluated the existence of parasympathetic neuropathy in relation to the glycemic status irrespective of the duration of diabetes.

Keywords

• Chronic hyperglycemia
• Parasympathetic neuropathy