Programmable biomaterials for bone regeneration

Peiran Song; Dongyang Zhou; Fuxiao Wang; Guangfeng Li; Long Bai; Jiacan Su

Materials Today Bio (Dec 2024)

Programmable biomaterials for bone regeneration

Peiran Song,
Dongyang Zhou,
Fuxiao Wang,
Guangfeng Li,
Long Bai,
Jiacan Su

Affiliations

Peiran Song: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China
Dongyang Zhou: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China
Fuxiao Wang: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China
Guangfeng Li: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Shanghaizhongye Hospital, Shanghai, 200941, China; Corresponding author. Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Long Bai: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Wenzhou Institute of Shanghai University, Wenzhou, 325000, China; Corresponding author. Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan Su: Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Corresponding author. Organoid Research Center, Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Journal volume & issue: Vol. 29
p. 101296

Abstract

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Programmable biomaterials are distinguished by their ability to adjust properties and functions on demand, in a periodic, reversible, or sequential manner. This contrasts with traditional biomaterials, which undergo irreversible, uncontrolled changes. This review synthesizes key advances in programmable biomaterials, examining their design principles, functionalities and applications in bone regeneration. It charts the transition from traditional to programmable biomaterials, emphasizing their enhanced precision, safety and control, which are critical from clinical and biosafety standpoints. We then classify programmable biomaterials into six types: dynamic nucleic acid-based biomaterials, electrically responsive biomaterials, bioactive scaffolds with programmable properties, nanomaterials for targeted bone regeneration, surface-engineered implants for sequential regeneration and stimuli-responsive release materials. Each category is analyzed for its structural properties and its impact on bone tissue engineering. Finally, the review further concludes by highlighting the challenges faced by programmable biomaterials and suggests integrating artificial intelligence and precision medicine to enhance their application in bone regeneration and other biomedical fields.

Published in Materials Today Bio

ISSN: 2590-0064 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/materials-today-bio

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