Nature Communications (Jun 2021)
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
- Laura Santini,
- Florian Halbritter,
- Fabian Titz-Teixeira,
- Toru Suzuki,
- Maki Asami,
- Xiaoyan Ma,
- Julia Ramesmayer,
- Andreas Lackner,
- Nick Warr,
- Florian Pauler,
- Simon Hippenmeyer,
- Ernest Laue,
- Matthias Farlik,
- Christoph Bock,
- Andreas Beyer,
- Anthony C. F. Perry,
- Martin Leeb
Affiliations
- Laura Santini
- Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter
- Florian Halbritter
- St. Anna Children’s Cancer Research Institute (CCRI)
- Fabian Titz-Teixeira
- Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne
- Toru Suzuki
- Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath
- Maki Asami
- Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath
- Xiaoyan Ma
- Department of Biochemistry, University of Cambridge
- Julia Ramesmayer
- Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter
- Andreas Lackner
- Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter
- Nick Warr
- Mammalian Genetics Unit, MRC Harwell Institute
- Florian Pauler
- Institute for Science and Technology Austria
- Simon Hippenmeyer
- Institute for Science and Technology Austria
- Ernest Laue
- Department of Biochemistry, University of Cambridge
- Matthias Farlik
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Christoph Bock
- CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
- Andreas Beyer
- Cologne Excellence Cluster Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne
- Anthony C. F. Perry
- Laboratory of Mammalian Molecular Embryology, Department of Biology and Biochemistry, University of Bath
- Martin Leeb
- Max Perutz Laboratories Vienna, University of Vienna, Vienna Biocenter
- DOI
- https://doi.org/10.1038/s41467-021-23510-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
In most mammals, imprinted genes contain epigenetic marks that differ in each parental genome and control their parent-of-origin-specific expression. Here, the authors map imprinted genes in mouse preimplantation embryos and find that imprinted gene expression in blastocysts is mainly dependent on Polycomb-mediated H3K27me3-associated gene silencing.
