Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome

Chensihan Huang; Deying Liu; Shunyu Yang; Yan Huang; Xueyun Wei; Peizhen Zhang; Jiayang Lin; Bingyan Xu; Yating Liu; Dan Guo; Yafeng Li; Jin Li; Huijie Zhang

iScience (Jul 2024)

Effect of time-restricted eating regimen on weight loss is mediated by gut microbiome

Chensihan Huang,
Deying Liu,
Shunyu Yang,
Yan Huang,
Xueyun Wei,
Peizhen Zhang,
Jiayang Lin,
Bingyan Xu,
Yating Liu,
Dan Guo,
Yafeng Li,
Jin Li,
Huijie Zhang

Affiliations

Chensihan Huang: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Deying Liu: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Shunyu Yang: Department of Nutrition, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Yan Huang: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Xueyun Wei: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Peizhen Zhang: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Jiayang Lin: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Bingyan Xu: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Yating Liu: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Dan Guo: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China
Yafeng Li: Department of Nephrology, Shanxi Provincial People’s Hospital (Fifth Hospital) of Shanxi Medical University, Taiyuan 030000, Shanxi, China; Core Laboratory, Shanxi Provincial People’s Hospital (Fifth Hospital) of Shanxi Medical University; Taiyuan, China; Academy of Microbial Ecology, Shanxi Medical University, Taiyuan 030000, Shanxi, China; Corresponding author
Jin Li: Department of Endocrinology and Metabolism, Shan Xi Medical University Second Hospital, Shan Xi Medical University, Taiyuan 030000, Shanxi, China; Corresponding author
Huijie Zhang: Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China; Corresponding author

Journal volume & issue: Vol. 27, no. 7
p. 110202

Abstract

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Summary: Time-restricted eating (TRE) is a promising obesity management strategy, but weight-loss efficacy varies among participants, and the underlying mechanism is unclear. The study aimed to investigate the role of gut microbiota in weight-loss response during long-term TRE intervention. We analyzed data from 51 obese adults in a 12-month TRE program, categorizing them into distinct weight loss groups (DG) and moderate weight loss groups (MG) based on their TRE responses. Shotgun metagenomic sequencing analysis revealed a significant increase in species closely associated with weight loss effectiveness and metabolic parameter changes in the DG group. Pathways related to fatty acid biosynthesis, glycogen biosynthesis, and nucleotide metabolism were reduced in the DG group and enhanced in the MG group. Next, we identified nine specific species at baseline that contributed better responses to TRE intervention and significant weight loss. Collectively, gut microbiota contributes to responsiveness heterogeneity in TRE and can predict weight-loss effectiveness.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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