Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage

Brian T. Chung; Yaewon Kim; Jeremy W. Gordon; Hsin-Yu Chen; Adam W. Autry; Philip M. Lee; Jasmine Y. Hu; Chou T. Tan; Chris Suszczynski; Susan M. Chang; Javier E. Villanueva-Meyer; Robert A. Bok; Peder E.Z. Larson; Duan Xu; Yan Li; Daniel B. Vigneron

NeuroImage (Oct 2023)

Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage

Brian T. Chung,
Yaewon Kim,
Jeremy W. Gordon,
Hsin-Yu Chen,
Adam W. Autry,
Philip M. Lee,
Jasmine Y. Hu,
Chou T. Tan,
Chris Suszczynski,
Susan M. Chang,
Javier E. Villanueva-Meyer,
Robert A. Bok,
Peder E.Z. Larson,
Duan Xu,
Yan Li,
Daniel B. Vigneron

Affiliations

Brian T. Chung: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA
Yaewon Kim: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; Corresponding author.
Jeremy W. Gordon: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Hsin-Yu Chen: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Adam W. Autry: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Philip M. Lee: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA
Jasmine Y. Hu: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA
Chou T. Tan: ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA
Chris Suszczynski: ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH 45342, USA
Susan M. Chang: Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA
Javier E. Villanueva-Meyer: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Robert A. Bok: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Peder E.Z. Larson: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA
Duan Xu: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA
Yan Li: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA
Daniel B. Vigneron: Department of Radiology and Biomedical Imaging, University of California, 1700 Fourth Street, Byers Hall Suite 102, San Francisco, CA 94158, USA; UCSF – UC Berkeley Graduate Program in Bioengineering, University of California, USA; Department of Neurological Surgery, University of California, San Francisco, CA 94158, USA

Journal volume & issue: Vol. 280
p. 120350

Abstract

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Hyperpolarized (HP) 13C Magnetic Resonance Imaging (MRI) was applied for the first time to image and quantify the uptake and metabolism of [2–13C]pyruvate in the human brain to provide new metabolic information on cerebral energy metabolism. HP [2–13C]pyruvate was injected intravenously and imaged in 5 healthy human volunteer exams with whole brain coverage in a 1-minute acquisition using a specialized spectral-spatial multi-slice echoplanar imaging (EPI) pulse sequence to acquire 13C-labeled volumetric and dynamic images of [2–13C]pyruvate and downstream metabolites [5–13C]glutamate and [2–13C]lactate. Metabolic ratios and apparent conversion rates of pyruvate-to-lactate (kPL) and pyruvate-to-glutamate (kPG) were quantified to investigate simultaneously glycolytic and oxidative metabolism in a single injection.

Published in NeuroImage

ISSN: 1053-8119 (Print); 1095-9572 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage

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