Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Bi-Dar Wang; Kristin Ceniccola; SuJin Hwang; Ramez Andrawis; Anelia Horvath; Jennifer A. Freedman; Jacqueline Olender; Stefan Knapp; Travers Ching; Lana Garmire; Vyomesh Patel; Mariano A. Garcia-Blanco; Steven R. Patierno; Norman H. Lee

doi:10.1038/ncomms15921

Nature Communications (Jun 2017)

Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer

Bi-Dar Wang,
Kristin Ceniccola,
SuJin Hwang,
Ramez Andrawis,
Anelia Horvath,
Jennifer A. Freedman,
Jacqueline Olender,
Stefan Knapp,
Travers Ching,
Lana Garmire,
Vyomesh Patel,
Mariano A. Garcia-Blanco,
Steven R. Patierno,
Norman H. Lee

Affiliations

Bi-Dar Wang: Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University
Kristin Ceniccola: Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University
SuJin Hwang: Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, The George Washington University
Ramez Andrawis: Department of Urology, School of Medicine and Health Sciences, The George Washington University
Anelia Horvath: Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University
Jennifer A. Freedman: Duke Cancer Institute and Department of Medicine, Duke University Medical Center
Jacqueline Olender: Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University
Stefan Knapp: Department of Clinical Pharmacology, University of Oxford
Travers Ching: Cancer Epidemiology Program, University of Hawaii Cancer Center
Lana Garmire: Cancer Epidemiology Program, University of Hawaii Cancer Center
Vyomesh Patel: Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health
Mariano A. Garcia-Blanco: Department of Biochemistry & Molecular Biology, The University of Texas Medical Branch at Galveston
Steven R. Patierno: Duke Cancer Institute and Department of Medicine, Duke University Medical Center
Norman H. Lee: Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University

DOI: https://doi.org/10.1038/ncomms15921
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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In prostate cancer tumour aggressiveness can be related to race. Here, the authors identify an alternative RNA splice variant of PIK3CD as a potential mechanism to explain racial disparities in the incidence and aggressiveness of prostate cancer between African American and European American men.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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