Nature Communications (Sep 2019)
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells
- Nilda Vanesa Ayala-Nunez,
- Gautier Follain,
- François Delalande,
- Aurélie Hirschler,
- Emma Partiot,
- Gillian L. Hale,
- Brigid C. Bollweg,
- Judith Roels,
- Maxime Chazal,
- Florian Bakoa,
- Margot Carocci,
- Sandrine Bourdoulous,
- Orestis Faklaris,
- Sherif R. Zaki,
- Anita Eckly,
- Béatrice Uring-Lambert,
- Frédéric Doussau,
- Sarah Cianferani,
- Christine Carapito,
- Frank M. J. Jacobs,
- Nolwenn Jouvenet,
- Jacky G. Goetz,
- Raphael Gaudin
Affiliations
- Nilda Vanesa Ayala-Nunez
- Institut de Recherche en Infectiologie de Montpellier (IRIM), CNRS, Université de Montpellier
- Gautier Follain
- INSERM U1109 and FMTS
- François Delalande
- Laboratoire de Spectrométrie de Masse Bio-Organique, IPHC, UMR 7178, CNRS-Université de Strasbourg, ECPM
- Aurélie Hirschler
- Laboratoire de Spectrométrie de Masse Bio-Organique, IPHC, UMR 7178, CNRS-Université de Strasbourg, ECPM
- Emma Partiot
- Institut de Recherche en Infectiologie de Montpellier (IRIM), CNRS, Université de Montpellier
- Gillian L. Hale
- Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention
- Brigid C. Bollweg
- Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention
- Judith Roels
- University of Amsterdam, Swammerdam Institute for Life Sciences
- Maxime Chazal
- Viral Genomics and Vaccination Unit, UMR3569 CNRS, Virology Department, Institut Pasteur
- Florian Bakoa
- Viral Genomics and Vaccination Unit, UMR3569 CNRS, Virology Department, Institut Pasteur
- Margot Carocci
- Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS
- Sandrine Bourdoulous
- INSERM U1016, Institut Cochin, CNRS UMR8104, Université Paris Descartes
- Orestis Faklaris
- MRI Core facility, Biocampus
- Sherif R. Zaki
- Infectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Centers for Disease Control and Prevention
- Anita Eckly
- Université de Strasbourg, INSERM, EFS Grand Est, BPPS UMR-S1255, FMTS
- Béatrice Uring-Lambert
- Hôpitaux universitaires de Strasbourg, laboratoire central d’immunologie
- Frédéric Doussau
- Institut des Neurosciences Cellulaires et Intégratives, CNRS, Université de Strasbourg
- Sarah Cianferani
- Laboratoire de Spectrométrie de Masse Bio-Organique, IPHC, UMR 7178, CNRS-Université de Strasbourg, ECPM
- Christine Carapito
- Laboratoire de Spectrométrie de Masse Bio-Organique, IPHC, UMR 7178, CNRS-Université de Strasbourg, ECPM
- Frank M. J. Jacobs
- University of Amsterdam, Swammerdam Institute for Life Sciences
- Nolwenn Jouvenet
- Viral Genomics and Vaccination Unit, UMR3569 CNRS, Virology Department, Institut Pasteur
- Jacky G. Goetz
- INSERM U1109 and FMTS
- Raphael Gaudin
- Institut de Recherche en Infectiologie de Montpellier (IRIM), CNRS, Université de Montpellier
- DOI
- https://doi.org/10.1038/s41467-019-12408-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Zika virus (ZIKV) can infect the central nervous system, but it is not clear how it reaches the brain. Here, Ayala-Nunez et al. show in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.
