The Study of SAD1/UNC-84 Domain Protein 1 in Muscle of Diabetic Male Wistar Rats

Abstract

Objective: The purpose of this study was to measure the changes of the SUN1 protein levels on soleus muscle in diabetic male wistar rats. Materials and Methods: Twenty male Wistar rats with 10 weeks old and weighing 200-250 grams were selected. After two weeks, the rats were divided into two groups (diabetic group and healthy group). After 12 hours fasting, diabetes was induced by intraperitoneally injection of streptozotocin (STZ). At the end of sixth week, the soleus muscle was removed and kept at a temperature of -80 degrees to evaluate the difference of SUN1 protein between two groups. Results: there was not significant difference in SUN1 protein levels between diabetic and control groups (P-value: 0.525). Conclusion: Although in most of laminopathies, the SUN1 protein that located in the inner nuclear membrane changed, but it seems the proteins in the inner membrane, are not affected by diabetes.

Keywords

• LINC complex
• SUN proteins
• Diabetes mellitus
• Soleus muscle
• Rats