Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Chi-Chun Yang; Masahiro Suzuki; Shiori Yamakawa; Syuzi Uno; Ai Ishii; Satoshi Yamazaki; Rino Fukatsu; Ryo Fujisawa; Kenji Sakimura; Toshiki Tsurimoto; Hisao Masai

doi:10.1038/ncomms12135

Nature Communications (Jul 2016)

Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells

Chi-Chun Yang,
Masahiro Suzuki,
Shiori Yamakawa,
Syuzi Uno,
Ai Ishii,
Satoshi Yamazaki,
Rino Fukatsu,
Ryo Fujisawa,
Kenji Sakimura,
Toshiki Tsurimoto,
Hisao Masai

Affiliations

Chi-Chun Yang: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Masahiro Suzuki: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Shiori Yamakawa: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Syuzi Uno: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Ai Ishii: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Satoshi Yamazaki: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Rino Fukatsu: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science
Ryo Fujisawa: Department of Biology, Faculty of Science, Kyushu University 744 Motooka, Nishi-ku
Kenji Sakimura: Department of Cellular Neurobiology, Brain Research Institute, Niigata University
Toshiki Tsurimoto: Department of Biology, Faculty of Science, Kyushu University 744 Motooka, Nishi-ku
Hisao Masai: Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science

DOI: https://doi.org/10.1038/ncomms12135
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Claspin mediates the transmission of a replication-stress signal from ATR to Chk1 and is necessary for efficient fork progression. Here the authors demonstrate that the C-terminal acidic patch is important for this role due to its interaction with Cdc7.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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