Primary biliary cholangitis, a rising health burden

Abstract

Primary biliary cholangitis (PBC) is a rare immune-mediated disease, commonly affecting women in their 40s, and ultimately progressing to liver failure. The incidence and prevalence of the disease are increasing worldwide, possibly due to better diagnostic tools. This review will focus on its epidemiology, pathophysiology, diagnosis, prognosis, and new developments in therapy.

Keywords

• primary biliary cholangitis
• cholestasis
• liver cirrhosis
• globe score
• antimitochondrial antibody
• management challenges