Nature Communications (Dec 2018)

Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption

  • Casper Larsen,
  • Anders Etzerodt,
  • Mette Madsen,
  • Karsten Skjødt,
  • Søren Kragh Moestrup,
  • Christian Brix Folsted Andersen

DOI
https://doi.org/10.1038/s41467-018-07468-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Cubilin and the transmembrane protein amnionless (AMN) form the endocytic receptor cubam that is essential for intestinal vitamin B12 uptake. Here the authors present the 2.3 Å crystal structure of AMN in complex with the amino-terminal region of cubilin and discuss cubam architecture and disease causing mutations.