CD46 facilitates entry and dissemination of human cytomegalovirus

Kathryn R. Stein; Thomas J. Gardner; Rosmel E. Hernandez; Thomas A. Kraus; James A. Duty; Iban Ubarretxena-Belandia; Thomas M. Moran; Domenico Tortorella

doi:10.1038/s41467-019-10587-1

Nature Communications (Jun 2019)

CD46 facilitates entry and dissemination of human cytomegalovirus

Kathryn R. Stein,
Thomas J. Gardner,
Rosmel E. Hernandez,
Thomas A. Kraus,
James A. Duty,
Iban Ubarretxena-Belandia,
Thomas M. Moran,
Domenico Tortorella

Affiliations

Kathryn R. Stein: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Thomas J. Gardner: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Rosmel E. Hernandez: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Thomas A. Kraus: Department of Microbiology, Icahn School of Medicine at Mount Sinai
James A. Duty: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Iban Ubarretxena-Belandia: Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
Thomas M. Moran: Department of Microbiology, Icahn School of Medicine at Mount Sinai
Domenico Tortorella: Department of Microbiology, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-019-10587-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Human cytomegalovirus (CMV) infects a wide range of host cells. Here, using a high throughput antibody screening platform, the authors identify the cell surface receptor CD46 to be required for CMV infection of epithelial cells and trophoblast-derived cells, the latter critical for congenital CMV infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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