Nature Communications (Nov 2021)
Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia
- Janek S. Walker,
- Zachary A. Hing,
- Steven Sher,
- James Cronin,
- Katie Williams,
- Bonnie Harrington,
- Jordan N. Skinner,
- Casey B. Cempre,
- Charles T. Gregory,
- Alexander Pan,
- Max Yano,
- Larry P. Beaver,
- Brandi R. Walker,
- Jadwiga M. Labanowska,
- Nyla A. Heerema,
- Krzysztof Mrózek,
- Jennifer A. Woyach,
- Amy S. Ruppert,
- Amy Lehman,
- Hatice Gulcin Ozer,
- Vincenzo Coppola,
- Pearlly Yan,
- John C. Byrd,
- James S. Blachly,
- Rosa Lapalombella
Affiliations
- Janek S. Walker
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Zachary A. Hing
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Steven Sher
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- James Cronin
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Katie Williams
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Bonnie Harrington
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Jordan N. Skinner
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Casey B. Cempre
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Charles T. Gregory
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Alexander Pan
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Max Yano
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Larry P. Beaver
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Brandi R. Walker
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Jadwiga M. Labanowska
- Department of Pathology, The Ohio State University
- Nyla A. Heerema
- Department of Pathology, The Ohio State University
- Krzysztof Mrózek
- The Ohio State University Comprehensive Cancer Center, Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University
- Jennifer A. Woyach
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Amy S. Ruppert
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Amy Lehman
- Center for Biostatistics, The Ohio State University
- Hatice Gulcin Ozer
- Department of Biomedical Informatics, The Ohio State University College of Medicine
- Vincenzo Coppola
- Department of Cancer Biology and Genetics, The Ohio State University College of Medicine
- Pearlly Yan
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- John C. Byrd
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- James S. Blachly
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- Rosa Lapalombella
- Division of Hematology, Department of Internal Medicine, The Ohio State University
- DOI
- https://doi.org/10.1038/s41467-021-26400-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a murine model.
