NEDDylation promotes stress granule assembly

Aravinth Kumar Jayabalan; Anthony Sanchez; Ra Young Park; Sang Pil Yoon; Gum-Yong Kang; Je-Hyun Baek; Paul Anderson; Younghoon Kee; Takbum Ohn

doi:10.1038/ncomms12125

Nature Communications (Jul 2016)

NEDDylation promotes stress granule assembly

Aravinth Kumar Jayabalan,
Anthony Sanchez,
Ra Young Park,
Sang Pil Yoon,
Gum-Yong Kang,
Je-Hyun Baek,
Paul Anderson,
Younghoon Kee,
Takbum Ohn

Affiliations

Aravinth Kumar Jayabalan: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University
Anthony Sanchez: Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida
Ra Young Park: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University
Sang Pil Yoon: Department of Anatomy, School of Medicine, Jeju National University
Gum-Yong Kang: Diatech Korea Co, Ltd
Je-Hyun Baek: Diatech Korea Co, Ltd
Paul Anderson: Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital
Younghoon Kee: Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida
Takbum Ohn: Department of Cellular & Molecular Medicine, College of Medicine, Chosun University

DOI: https://doi.org/10.1038/ncomms12125
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to arsenite exposure.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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