Nature Communications (Sep 2019)
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
- Alexander Teumer,
- Yong Li,
- Sahar Ghasemi,
- Bram P. Prins,
- Matthias Wuttke,
- Tobias Hermle,
- Ayush Giri,
- Karsten B. Sieber,
- Chengxiang Qiu,
- Holger Kirsten,
- Adrienne Tin,
- Audrey Y. Chu,
- Nisha Bansal,
- Mary F. Feitosa,
- Lihua Wang,
- Jin-Fang Chai,
- Massimiliano Cocca,
- Christian Fuchsberger,
- Mathias Gorski,
- Anselm Hoppmann,
- Katrin Horn,
- Man Li,
- Jonathan Marten,
- Damia Noce,
- Teresa Nutile,
- Sanaz Sedaghat,
- Gardar Sveinbjornsson,
- Bamidele O. Tayo,
- Peter J. van der Most,
- Yizhe Xu,
- Zhi Yu,
- Lea Gerstner,
- Johan Ärnlöv,
- Stephan J. L. Bakker,
- Daniela Baptista,
- Mary L. Biggs,
- Eric Boerwinkle,
- Hermann Brenner,
- Ralph Burkhardt,
- Robert J. Carroll,
- Miao-Li Chee,
- Miao-Ling Chee,
- Mengmeng Chen,
- Ching-Yu Cheng,
- James P. Cook,
- Josef Coresh,
- Tanguy Corre,
- John Danesh,
- Martin H. de Borst,
- Alessandro De Grandi,
- Renée de Mutsert,
- Aiko P. J. de Vries,
- Frauke Degenhardt,
- Katalin Dittrich,
- Jasmin Divers,
- Kai-Uwe Eckardt,
- Georg Ehret,
- Karlhans Endlich,
- Janine F. Felix,
- Oscar H. Franco,
- Andre Franke,
- Barry I. Freedman,
- Sandra Freitag-Wolf,
- Ron T. Gansevoort,
- Vilmantas Giedraitis,
- Martin Gögele,
- Franziska Grundner-Culemann,
- Daniel F. Gudbjartsson,
- Vilmundur Gudnason,
- Pavel Hamet,
- Tamara B. Harris,
- Andrew A. Hicks,
- Hilma Holm,
- Valencia Hui Xian Foo,
- Shih-Jen Hwang,
- M. Arfan Ikram,
- Erik Ingelsson,
- Vincent W. V. Jaddoe,
- Johanna Jakobsdottir,
- Navya Shilpa Josyula,
- Bettina Jung,
- Mika Kähönen,
- Chiea-Chuen Khor,
- Wieland Kiess,
- Wolfgang Koenig,
- Antje Körner,
- Peter Kovacs,
- Holly Kramer,
- Bernhard K. Krämer,
- Florian Kronenberg,
- Leslie A. Lange,
- Carl D. Langefeld,
- Jeannette Jen-Mai Lee,
- Terho Lehtimäki,
- Wolfgang Lieb,
- Su-Chi Lim,
- Lars Lind,
- Cecilia M. Lindgren,
- Jianjun Liu,
- Markus Loeffler,
- Leo-Pekka Lyytikäinen,
- Anubha Mahajan,
- Joseph C. Maranville,
- Deborah Mascalzoni,
- Barbara McMullen,
- Christa Meisinger,
- Thomas Meitinger,
- Kozeta Miliku,
- Dennis O. Mook-Kanamori,
- Martina Müller-Nurasyid,
- Josyf C. Mychaleckyj,
- Matthias Nauck,
- Kjell Nikus,
- Boting Ning,
- Raymond Noordam,
- Jeffrey O’ Connell,
- Isleifur Olafsson,
- Nicholette D. Palmer,
- Annette Peters,
- Anna I. Podgornaia,
- Belen Ponte,
- Tanja Poulain,
- Peter P. Pramstaller,
- Ton J. Rabelink,
- Laura M. Raffield,
- Dermot F. Reilly,
- Rainer Rettig,
- Myriam Rheinberger,
- Kenneth M. Rice,
- Fernando Rivadeneira,
- Heiko Runz,
- Kathleen A. Ryan,
- Charumathi Sabanayagam,
- Kai-Uwe Saum,
- Ben Schöttker,
- Christian M. Shaffer,
- Yuan Shi,
- Albert V. Smith,
- Konstantin Strauch,
- Michael Stumvoll,
- Benjamin B. Sun,
- Silke Szymczak,
- E-Shyong Tai,
- Nicholas Y. Q. Tan,
- Kent D. Taylor,
- Andrej Teren,
- Yih-Chung Tham,
- Joachim Thiery,
- Chris H. L. Thio,
- Hauke Thomsen,
- Unnur Thorsteinsdottir,
- Anke Tönjes,
- Johanne Tremblay,
- André G. Uitterlinden,
- Pim van der Harst,
- Niek Verweij,
- Suzanne Vogelezang,
- Uwe Völker,
- Melanie Waldenberger,
- Chaolong Wang,
- Otis D. Wilson,
- Charlene Wong,
- Tien-Yin Wong,
- Qiong Yang,
- Masayuki Yasuda,
- Shreeram Akilesh,
- Murielle Bochud,
- Carsten A. Böger,
- Olivier Devuyst,
- Todd L. Edwards,
- Kevin Ho,
- Andrew P. Morris,
- Afshin Parsa,
- Sarah A. Pendergrass,
- Bruce M. Psaty,
- Jerome I. Rotter,
- Kari Stefansson,
- James G. Wilson,
- Katalin Susztak,
- Harold Snieder,
- Iris M. Heid,
- Markus Scholz,
- Adam S. Butterworth,
- Adriana M. Hung,
- Cristian Pattaro,
- Anna Köttgen
Affiliations
- Alexander Teumer
- Institute for Community Medicine, University Medicine Greifswald
- Yong Li
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg
- Sahar Ghasemi
- Institute for Community Medicine, University Medicine Greifswald
- Bram P. Prins
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Matthias Wuttke
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg
- Tobias Hermle
- Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg
- Ayush Giri
- Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center
- Karsten B. Sieber
- Target Sciences - Genetics, GlaxoSmithKline
- Chengxiang Qiu
- Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Holger Kirsten
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Adrienne Tin
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Audrey Y. Chu
- Genetics, Merck & Co., Inc.
- Nisha Bansal
- Division of Nephrology, University of Washington
- Mary F. Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Lihua Wang
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Jin-Fang Chai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Massimiliano Cocca
- Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”
- Christian Fuchsberger
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Mathias Gorski
- Department of Nephrology, University Hospital Regensburg
- Anselm Hoppmann
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg
- Katrin Horn
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Man Li
- Department of Medicine, Division of Nephrology and Hypertension, University of Utah
- Jonathan Marten
- Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Damia Noce
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Teresa Nutile
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Sanaz Sedaghat
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Gardar Sveinbjornsson
- deCODE Genetics, Amgen Inc.
- Bamidele O. Tayo
- Department of Public Health Sciences, Loyola University Chicago
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Yizhe Xu
- Department of Medicine, Division of Nephrology and Hypertension, University of Utah
- Zhi Yu
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Lea Gerstner
- Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg
- Johan Ärnlöv
- Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet
- Stephan J. L. Bakker
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Daniela Baptista
- Cardiology, Geneva University Hospitals
- Mary L. Biggs
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Eric Boerwinkle
- Human Genetics Centre, University of Texas Health Science Centre
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ)
- Ralph Burkhardt
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Robert J. Carroll
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Miao-Li Chee
- Singapore Eye Research Institute, Singapore National Eye Centre
- Miao-Ling Chee
- Singapore Eye Research Institute, Singapore National Eye Centre
- Mengmeng Chen
- Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- James P. Cook
- Department of Biostatistics, University of Liverpool
- Josef Coresh
- Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health
- Tanguy Corre
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- John Danesh
- Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge
- Martin H. de Borst
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Alessandro De Grandi
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Renée de Mutsert
- Department of Clinical Epidemiology, Leiden University Medical Centre
- Aiko P. J. de Vries
- Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre
- Frauke Degenhardt
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Katalin Dittrich
- Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig
- Jasmin Divers
- Department of Biostatistics and Data Science, Wake Forest School of Medicine
- Kai-Uwe Eckardt
- Intensive Care Medicine, Charité
- Georg Ehret
- Cardiology, Geneva University Hospitals
- Karlhans Endlich
- DZHK (German Center for Cardiovascular Research), Partner Site Greifswald
- Janine F. Felix
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Oscar H. Franco
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Barry I. Freedman
- Internal Medicine - Section on Nephrology, Wake Forest School of Medicine
- Sandra Freitag-Wolf
- Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein
- Ron T. Gansevoort
- Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University
- Martin Gögele
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Franziska Grundner-Culemann
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg
- Daniel F. Gudbjartsson
- deCODE Genetics, Amgen Inc.
- Vilmundur Gudnason
- Icelandic Heart Association
- Pavel Hamet
- Montreal University Hospital Research Centre, CHUM
- Tamara B. Harris
- Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health
- Andrew A. Hicks
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Hilma Holm
- deCODE Genetics, Amgen Inc.
- Valencia Hui Xian Foo
- Singapore Eye Research Institute, Singapore National Eye Centre
- Shih-Jen Hwang
- NHLBI’s Framingham Heart Study
- M. Arfan Ikram
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Vincent W. V. Jaddoe
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Johanna Jakobsdottir
- Icelandic Heart Association, Holtasmari 1
- Navya Shilpa Josyula
- Geisinger Research, Biomedical and Translational Informatics Institute
- Bettina Jung
- Department of Nephrology, University Hospital Regensburg
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Chiea-Chuen Khor
- Singapore Eye Research Institute, Singapore National Eye Centre
- Wieland Kiess
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Wolfgang Koenig
- Deutsches Herzzentrum München, Technische Universität München
- Antje Körner
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Peter Kovacs
- Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig
- Holly Kramer
- Department of Public Health Sciences, Loyola University Chicago
- Bernhard K. Krämer
- 5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg
- Florian Kronenberg
- Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck
- Leslie A. Lange
- Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus
- Carl D. Langefeld
- Department of Biostatistics and Data Science, Wake Forest School of Medicine
- Jeannette Jen-Mai Lee
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Wolfgang Lieb
- Institute of Epidemiology and Biobank Popgen, Kiel University
- Su-Chi Lim
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Lars Lind
- Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University
- Cecilia M. Lindgren
- Nuffield Department of Medicine, University of Oxford
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science Technology and Research
- Markus Loeffler
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Anubha Mahajan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Joseph C. Maranville
- MRL, Merck & Co., Inc.
- Deborah Mascalzoni
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Barbara McMullen
- Vanderbilt University School of Medicine
- Christa Meisinger
- Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health
- Thomas Meitinger
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Kozeta Miliku
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Centre
- Martina Müller-Nurasyid
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health
- Josyf C. Mychaleckyj
- Centre for Public Health Genomics, University of Virginia
- Matthias Nauck
- DZHK (German Center for Cardiovascular Research), Partner Site Greifswald
- Kjell Nikus
- Department of Cardiology, Heart Center, Tampere University Hospital
- Boting Ning
- Department of Biostatistics, Boston University School of Public Health
- Raymond Noordam
- Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre
- Jeffrey O’ Connell
- University of Maryland School of Medicine
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali University Hospital
- Nicholette D. Palmer
- Biochemistry, Wake Forest School of Medicine
- Annette Peters
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Anna I. Podgornaia
- Genetics, Merck & Co., Inc.
- Belen Ponte
- Service de Néphrologie, Geneva University Hospitals
- Tanja Poulain
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Peter P. Pramstaller
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Ton J. Rabelink
- Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre
- Laura M. Raffield
- Department of Genetics, University of North Carolina
- Dermot F. Reilly
- Genetics, Merck & Co., Inc.
- Rainer Rettig
- Institute of Physiology, University Medicine Greifswald
- Myriam Rheinberger
- Department of Nephrology, University Hospital Regensburg
- Kenneth M. Rice
- Department of Biostatistics, University of Washington
- Fernando Rivadeneira
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Heiko Runz
- MRL, Merck & Co., Inc.
- Kathleen A. Ryan
- Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine
- Charumathi Sabanayagam
- Singapore Eye Research Institute, Singapore National Eye Centre
- Kai-Uwe Saum
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ)
- Ben Schöttker
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ)
- Christian M. Shaffer
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Yuan Shi
- Singapore Eye Research Institute, Singapore National Eye Centre
- Albert V. Smith
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Konstantin Strauch
- Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health
- Michael Stumvoll
- Department of Endocrinology and Nephrology, University of Leipzig
- Benjamin B. Sun
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Silke Szymczak
- Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein
- E-Shyong Tai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Nicholas Y. Q. Tan
- Singapore Eye Research Institute, Singapore National Eye Centre
- Kent D. Taylor
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Andrej Teren
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Yih-Chung Tham
- Singapore Eye Research Institute, Singapore National Eye Centre
- Joachim Thiery
- LIFE Research Centre for Civilization Diseases, University of Leipzig
- Chris H. L. Thio
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Hauke Thomsen
- Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ)
- Unnur Thorsteinsdottir
- deCODE Genetics, Amgen Inc.
- Anke Tönjes
- Department of Endocrinology and Nephrology, University of Leipzig
- Johanne Tremblay
- Montreal University Hospital Research Centre, CHUM
- André G. Uitterlinden
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Suzanne Vogelezang
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Uwe Völker
- DZHK (German Center for Cardiovascular Research), Partner Site Greifswald
- Melanie Waldenberger
- DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance
- Chaolong Wang
- Genome Institute of Singapore, Agency for Science Technology and Research
- Otis D. Wilson
- Vanderbilt University Medical Centre, Division of Nephrology & Hypertension
- Charlene Wong
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System
- Tien-Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- Qiong Yang
- Department of Biostatistics, Boston University School of Public Health
- Masayuki Yasuda
- Singapore Eye Research Institute, Singapore National Eye Centre
- Shreeram Akilesh
- Kidney Research Institute, University of Washington
- Murielle Bochud
- Center for Primary Care and Public Health (Unisanté), University of Lausanne
- Carsten A. Böger
- Department of Nephrology, University Hospital Regensburg
- Olivier Devuyst
- Institute of Physiology, University of Zurich
- Todd L. Edwards
- Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre
- Kevin Ho
- Kidney Health Research Institute (KHRI), Geisinger
- Andrew P. Morris
- Department of Biostatistics, University of Liverpool
- Afshin Parsa
- Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
- Sarah A. Pendergrass
- Geisinger Research, Biomedical and Translational Informatics Institute
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Kari Stefansson
- deCODE Genetics, Amgen Inc.
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Centre
- Katalin Susztak
- Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Iris M. Heid
- Department of Genetic Epidemiology, University of Regensburg
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Adam S. Butterworth
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Adriana M. Hung
- Vanderbilt University Medical Centre, Division of Nephrology & Hypertension
- Cristian Pattaro
- Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck)
- Anna Köttgen
- Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-019-11576-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 19
Abstract
Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.
