POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION

Abstract

XRCC1 Arg280His, XRCC2 Arg188His, XRCC3 Thr241Met genes polymorphism in lung cancer patients and healthy people of Kemerovo region has been studied. It is established that in the studied samples of distribution of frequencies of alleles and genotypes of the studied polymorphic markers had no deviation from Hardy-Weinberg equilibrium. The prevalence of XRCC3Met in the group of patients with lung cancer is statistically significantly higher than in healthy people. Also, there was a decrease in the frequency of Thr/Thr homozygotes of the XRCC3 gene in male patients with lung cancer. The obtained data are of significant interest for epidemiological studies of hereditary predisposition to the development of lung cancer.

Keywords

• xrcc1
• xrcc2
• xrcc3 genes polymorphism
• lung cancer